Publications

For a complete listing of publications on PubMed, click here

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Jacob Stewart-Ornstein, Galit Lahav. Integrating genomic information and signaling dynamics for efficient cancer therapy. Current Opinion in Systems Biology 2017, 1:3843 PDF

Sheng-hong Chen and Galit Lahav. Two is better than one; toward a rational design of combinatorial therapy. Current Opinion in Structural Biology 2016, 41:145-150 PDF

Nir Drayman, Orly Ben-nun-Shaul, Veronika Butin-Israeli, Rohit Srivastava, Ariel M. Rubinstein, Caroline S. Mock, Ela Elyada, Yinon Ben-Neriah, Galit Lahav and Ariella Oppenheim. p53 elevation in human cells halt SV40 infection by inhibiting T-ag expression. Oncotarget, 2016 PDF

Andrew L. Paek, Julia C. Liu, Alexander Loewer, William C. Forrester and Galit Lahav. Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing. Cell, 2016 PDF

Sheng-hong Chen, William Forrester and Galit Lahav. Schedule-dependent interaction between anticancer treatments. Science, 2016, 351:1204-1208; Full text PDF

Jacob Stewart-Ornstein and Galit Lahav. Dynamics of CDKN1A in Single Cells Defined by an Endogenous Fluorescent Tagging Toolkit. Cell Reports, 2016, 14:1-12; PDF

Laura Lande-Diner, Jacob Stewart-Ornstein, Charles J. Weitz and Galit Lahav. Single cell analysis of circa dian dynamics in tissue explants. Molecular Biology of the Cell, 2015; PDF

Giorgio Gaglia and Galit Lahav Constant rate of p53 tetramerization in response to DNA damage controls the p53 response. Molecular Systems Biology, 2014, 10:753:1 PDF.

Julia C. Liu, Paul H. Lerou and Galit Lahav. Stem cells: balancing resistance and sensitivity to DNA damage. Trends in Cell Biology, 2014, 1043:1; PDF.

Alexander Loewer, Ketki Karanam, Caroline Mock, and Galit Lahav. The p53 response in single cells in linearly correlated to the number of DNA breaks without a distinct threshold. BMC Biology, 2013, 11:114; PDF.

Giorgio Gaglia, Yinghu Guana, Jagesh V. Shaha, and Galit Lahav. Activation and control of p53 tetramerization in individual living cells PNAS, 2013; PDF.

Julia C. Liu, Xiao Guan, Jeremy A. Ryan, Ana G. Rivera, Caroline Mock, Vishesh Agarwal, Anthony Letai, Paul H. Lerou, and Galit Lahav. High Mitochondrial Priming Sensitizes hESCs to DNA-Damage-Induced Apoptosis Cell Stem Cell, 2013; 13: 1-9 PDF. Preview PDF

Ran Kafri, Jason Levy, Miriam B. Ginzberg, Seungeun Oh, Galit Lahav & Marc W. Kirschner. Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle Nature, 2013; 494: 480-483 PDF.

Jeremy Purvis and Galit Lahav. Encoding and Decoding Cellular Information through Signaling Dynamics Cell, 2013; 152:945-956 PDF.

Ketki Karanam, Alexander Loewer and Galit Lahav. Dynamics of the DNA damage response: insights fromlive-cell imaging Briefings in Functional Genomics, 2013; 8:1-9 PDF.

Ketki Karanam, Ran Kafri, Alexander Loewer and Galit Lahav. Quantitative Live Cell Imaging Reveals a Gradual Shift between DNA Repair Mechanisms and a Maximal Use of HR in Mid S Phase. Molecular Cell, 2012; 47:320-329 PDF

Jeremy E. Purvis and Galit Lahav. Decoding the Insulin Signal. Molecular Cell, 2012; 46:715-716 PDF

Jeremy E. Purvis, Kyle W. Karhohs, Caroline Mock, Eric Batchelor,
Alexander Loewer, Galit Lahav. p53 Dynamics Control Cell Fate. Science 2012: 336:1440-4 PDF

James D. Orth, Alexander Loewer, Galit Lahav, and Timothy J. Mitchison. Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction. Molecular Biology of the Cell 2012; 23:567-76 PDF

Alexander Loewer and Galit Lahav. We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells. Current Opinion in Genetics and Development 2011; 21:1-6 PDF

Eric Batchelor and Galit Lahav. Suppressing Variation in Synthetic Circuts. Molecular Systems Biology 2011; 7:520. PDF

Eric Batchelor, Alexander Loewer, Caroline Mock and Galit Lahav. Stimulus-dependent dynamics of p53 in single cells. Molecular Systems Biology 2011; 7: 488 PDF (See also Editor's choice in Science Signaling 2011; 4(174): p. ec149)

Jared Toettcher, Caroline Mock, Eric Batchelor, Alexander Loewer and Galit Lahav. A synthetic-natural hybrid oscillator in human cells. PNAS 2010; 107(36) PDF

Hiroyuki Inuzuka, Alan Tseng, Daming Gao, Bo Zhai, Qing Zhang, Shavali Shaik, Lixin Wan, Xiaolu L. Ang, Caroline Mock, Haoqiang Yin, Jayne M. Stommel, Steven Gygi, Galit Lahav, John Asara, Zhi-Xiong Jim Xiao, William G. Kaelin, J. Wade Harper, Wenyi Wei. Phosphorylation by Casein Kinase I Promotes the Turnover of the Mdm2 Oncoprotein via the SCFβ-TRCP Ubiquitin Ligase. Cancer Cell 2010; 18(2):47-159 PDF

Naama Geva-Zatorsky, Erez Dekel, Eric Batchelor, Galit Lahav and Uri Alon. Fourier analysis and systems identification of the p53 feedback loop. PNAS 2010; 107(30):13550-5 PDF

Alexander Loewer, Eric Batchelor, Giorgio Gaglia and Galit Lahav. Basal dynamics of p53 reveals transcriptionally attenuated pulses in cycling cells. Cell 2010; 142(1):89-100 PDF (See also Comment in Cell: PDF)

Amit Tzur, Ran Kafri, Valerie S. LeBleu, Galit Lahav and Marc W. Kirschner. Cell Growth and Size Homeostasis in Proliferating Animal Cells. Science 2009; 325: 167-171 PDF (See also Comment in Science: PDF)

Eric Batchelor, Alexander Loewer and Galit Lahav. The ups and downs of p53: understanding protein dynamics in single cells. Nature Reviews Cancer 2009; 9: 371-377 PDF

Jared E. Toettcher, Alexander Loewer, Gerard J. Ostheimerd, Michael B. Yaffe, Bruce Tidor and Galit Lahav. Distinct mechanisms act in concert to mediate cell cycle arrest. PNAS 2009; 106 (3): 785-790 PDF

Leonid Peshkin, Joaquin Goni, Alexander Loewer, Ram S. Kolluri, Galit Lahav and Dennis Wall. Morphology from Texture in Cytometry, International Journal of Tomography & Statistics 2009; 16, Issue No. S10

Galit Lahav. Oscillations by the p53-Mdm2 feedback loop. Adv Exp Med Biol. 2008; 641:28-38.PDF

Eric Batchelor, Caroline S. Mock, Irun Bhan, Alexander Loewer & Galit Lahav. Recurrent Initiation: A Mechanism for Triggering p53 Pulses in Response to DNA Damage. Molecular Cell, 2008; 30(3): 277-289. PDF

Naama Geva-Zatorsky, Nitzan Rosenfeld, Shalev Itzkovitz, Ron Milo, Alex Sigal, Erez Dekel, Talia Yarnitsky, Paz Pollack, Yuvalal Liron, Zvi Kam, Galit Lahav and Uri Alon. Oscillations and variability in the p53 system. Molecular Systems Biology, 2006; 2: E1-E13. PDF

Alex Sigal, Ron Milo, Ariel Cohen, Naama Geva-Zatorsky, Yael Klein, Inbal Alaluf, Naamah Swerdlin, Natalie Pertsov, Tamar Danon, Tal Raveh, Anne Carpenter, Galit Lahav and Uri Alon. Widespread cell-cycle dependence of nuclear proteins reveals by dynamic proteomics in individual living cells. Nature Methods, 2006 Jul; 3(7):525-31. PDF

Alexander Loewer and Galit Lahav. Cellular Conference Call: External Feedback Affects Cell Fate Decisions. Cell, 2006; 124: 1128-1130. PDF

Galit Lahav. The Strength of Indecisiveness: Oscillatory Behavior for Better Cell Fate Determination. Science STKE, 2004, 264, pe55 PDF

Galit Lahav, Nitzan Rosenfeld, Alex Sigal, Naama Geva-Zatorsky, Arnold J. Levine, Michael B. Elowitz and Uri Alon. Dynamics of the p53-mdm2 feedback loop in individual cells. Nature Genetics, 2004; 36 (2):147-50. PDF

Yona Kassir, Noam Adir, Elisabeth Boger-Nadjar, Noga Guttmann Raviv, Ifat Rubin Bejerano, Shira Sagee and Galit Shenhar. Transcriptional regulation of meiosis in budding yeast. Int Rev Cytol. 2003; 224: 111-71.

Galit Shenhar and Yona Kassir. A positive regulator of mitosis, Sok2, functions as a negative regulator of meiosis in Saccharomyces cerevisiae. Mol. Cell. Biol. 2001; 21(5):1603-12. PDF

Shira Sagee*, Amir Sherman*, Galit Shenhar*, Keneth Robzyk, Noa Ben-Dov, Giora Simchen and Yona Kassir. Multiple and distinct Activation and Repression Sequences mediate the regulate transcription of IME1, a transcriptional activator of meiosis specific genes in Saccharomyces cerevisiae. (* S.S, A.S and G.S contributed equally to this article). Mol. Cell. Biol. 1998; 18(4):1985-95. PDF